Knowledge of the fate (Absorption, Distribution, Metabolism, Elimination) of a test substance is necessary to predict its action on a test subject. With Attentive, you have at your disposal a wide range of in-vivo test systems as well as protocols and reporting infrastructure to ensure you receive quality data in a timely manner to select the best test substance and doses for your programs. Attentive Scientists bring the experience necessary to excel at executing these studies to assist you by performing in-vivo studies during the discovery and lead optimization phases of your research.
A test substance/compound that is going to be used to treat a disease needs to be biologically active, absorbed, distributed, metabolized and excreted. In-vivo dose formulations that will be administered to a test system require testing. Attentive Science can execute the pharmacokinetic assessment of your compound/test substance to allow you to get a quick read on if you have a “druggable” product.
During the early discovery phases of development, characterization of relatively longer half-life substances, be it a small molecule, biologic or an extended-release formulation, may be incomplete due to the extended absorption or elimination phases. It is critical to fully characterize any long-term pharmacokinetic profiles to fully understand how the test substance behaves In-vivo.
Standard and specialty dose routes are selected to mimic your intended clinical route of administration and alignment with your future clinical programs: PO (Oral); IV (Intravenous); SC (Subcutaneous); IM (Intramuscular); IP (Intraperitoneal Dermal); Intra-cerebral, Intra-thecal, Intra-articular etc.
Scientific integrity, quality, cost-effectiveness and regulatory compliance are essential considerations when you are selecting an outsourcing partner. Attentive Science partners with carefully selected specialty organizations for any nonclinical functions such as histopathology that are not performed in-house. Being experts, we like to work with other expert organizations.
Upon administration of a test substance to a test system, the pharmacokinetic and toxicity profile can also be dependent on the varying formulation that was used during discovery. Attentive Science will take your compound/test substance and formulate it in several vehicles (based on the type of molecule and utilizing our collective experience), and will administer it directly into a test system, collect blood samples in a timely fashion to determine if the test substance is present or not, as well as provide pharmacokinetic data endpoints.