PK
Knowledge of the fate (Absorption, Distribution, Metabolism, Elimination) of a test substance is necessary to predict its action on a test subject. With Attentive, you have at your disposal a wide range of in-vivo test systems as well as protocols and reporting infrastructure to ensure you receive quality data in a timely manner to select the best test substance and doses for your safety assessments. Once dosing is initiated, integrated partners provide support all the way through bioanalysis and reporting. Summary reports are available within 5 days of dosing/end of in-life.
Both rodent and non-rodents are available to assist with your assessment: Your intended clinical dose routes (PO, IV, IP, SC, IM, dermal, therapy specific) can be mimicked to ensure alignment with your future clinical programs.
Multiple test substances can also be evaluated concurrently to allow for increased efficiency.
Tox
Acute and Dose Range Finding: Prediction of acute effects on target organs subsequent to administration of your test substance is an essential data point. The data obtained helps guide your design and dose selection for subsequent subchronic and chronic studies. With Attentive, you have additional repertoire of in-vivo test systems to help you evaluate potential acute effects.
Subchronic and Chronic Toxicity Studies: Using a battery of assessments, these studies are designed for you to be able to detect physiological and pathological effects of a test substance.
Your intended clinical dose routes (PO, IV, IP, SC, IM, dermal, therapy specific) can be mimicked to ensure alignment with your future clinical programs for all your toxicity studies.
SEND: Standard for Exchange of Nonclinical Data capabilities are available by employing industry standard data acquisition systems.
Safety Pharm
Safety Pharmacology studies are designed to detect the potential undesirable pharmacodynamic effects of new chemical entities on physiological functions in relation to exposure in the therapeutic range and above . In addition to you obtaining scientifically robust data, you have access to a vast network of experts at Attentive.
Cardiovascular, Central Nervous System and Respiratory assessments (Core battery) are performed to exceed your expectations and to meet regulatory guidelines.
Both rodent and non-rodents available to assist with your assessment. Your intended clinical dose routes (PO, IV, IP, SC, IM, dermal) can be mimicked to ensure alignment with your future clinical programs.
Animal Health
Companion animal health and safety is important to one health initiative. From management of weight loss of your best companion through to treatment of ailments or severe chronic conditions, You have a range of alternatives available to you with Attentive.
Pharmacology Models
Design specific efficacy testing. Your models can be as unique as your company. Collaborating with you ensures your goals are met.